EXTREME ANOXIA TOLERANCE IN CRUCIAN CARP AND GOLDFISH THROUGH NEOFUNCTIONALIZATION OF DUPLICATED GENES CREATING A NEW ETHANOL-PRODUCING PYRUVATE DECARBOXYLASE PATHWAY

Abstract Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism.However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to survive prolonged periods without oxygen by producing ethanol as their metabolic end-produ

Corruption represents one of the major causes of poverty all over the world and European Union is fighting against it.In the last few years, the corruption phenomenon registered a high level in some European countries and became one of the most problematic factors for doing business, due to the evolution of the perceived top five global Suits risks

Bixin and norbixin are natural food colourants synthesised from Bixa orellana L seeds.This study explores the mechanism of apocarotenoids (bixin and norbixin) on the aggressive B16 murine melanoma as an anti-cancer agent.The apocarotenoids inhibited the cell viability of B16 melanoma in a time- and concentration-dependent manner.Apocarotenoids mark

Abstract Background Relapsed childhood polymicrobial osteomyelitis associated with dermatophytosis has not been reported in the literature.Case presentation Here we report on a case of a 45-year-old man who had left tibial osteomyelitis for 29 years, accompanied by skin fungal infection of the ipsilateral heel for 20 years, and underwent a second o

Abstract Background Fluralaner (Bravecto®, Merck Animal Health, Madison, NJ, USA) is a novel isoxazoline that provides up to 12 weeks flea and tick control when administered orally to dogs.Two assessor-blinded studies, one in dogs, the other in cats evaluated the sustained efficacy of a topical fluralaner formulation against fleas in a simulated h